The delta-9-THC in your edible will transform into 11-Hydroxy-THC when it passes through the liver of your gastrointestinal tract, which can take up to two hours to occur depending on your metabolism, what you’ve eaten, blood sugar, and other factors. Effects typically last 4-6 hours. According to The National Organization for the Reform of Marijuana Laws (NORML), ingested 11- Hydroxy-THC can be felt up to four to five times stronger than inhaled Delta-9-THC.